Abstract: In the ontology and epistemology, there is a fundamental transformation from the substantialist reification to the relationalist worldview of things in the history of modern thought. Kant, Mach, Husserl and Heidegger mistakenly attributed the reification in the daily experiences to the worldview of things which regards the relationship as the first. And the methodology of contemporary natural science, especially Einstein’s theory of relativity and the scientific advances of quantum mechanics have further confirmed this relational ontology. Thus, the dualistic structure of " subject-object” in traditional epistemology is replaced by the cognitive model of the four-limb structure of " what-given of appearance and what-recognized of meaning” and " learnable-who and recognizable-someone”. This new epistemological conception is more closer to our orientalist theory of integrated bodied knowing.