Abstract: The practices of world economy growth are undergoing profound changes. The traditional theories and methods of economy growth that based on the theory of production factor function are facing great challenges brought by a series of new practical changes. Major new variables and factors, such as the global pandemic of the COVID-19, new changes in international investment and trade rules, the regionalization of the global economy, the spillover effect of major countries’ economic policies, the Belt and Road initiative, the new development pattern of double cycles in China, the implementation of the global carbon reduction strategy, big data and AI, are profoundly impacting and changing the traditional world economy growth pattern, and also objectively affecting and reshaping the world economy’s speed, total amount, and resource allocation structure, enterprise organization, industrial structure, regulation structure and its new mechanism of total factor productivity; at the same time, all these new factors actually have potentially promoted the innovation and development of the theory of world economy growth. Theoretical research and innovative development need to introduce these new variables and factors into the traditional analysis framework to build and form a unified and comprehensive new analysis framework for world economy growth. This is a new direction and potential for the innovation and development of world economy growth theories, including national economic development theories.