Abstract: As one of China’s most economically active and most mature urban agglomerations, the Yangtze River Delta has a solid economic foundation and a distinctive regional cooperation model, which is the most conducive region for China to realize modernization and integration. Rising to national strategy marks a new stage of integration in the Yangtze River Delta. Based on the strategic judgment of the new stage and the new mission undertaken by the Yangtze River Delta, this paper argues that the integration of the Yangtze River Delta must properly deal with several types of relationships, including the “quality and quantity”, “big and small”, “same and different”, “strip and block” .We should focus on both quantity and quality to improve development efficiency through economic agglomeration. Distinguish the size of space to advance the integrated national strategy in an orderly manner. Unify similarities and differences, to enhance strengths and avoid weaknesses, and to guide the development of urban differentiation and characteristics. Contact strip and block, to promote the development of block economy such as metropolitan area with the construction of transportation economic belt.