Abstract: Growth triangle is a relatively mature model of regional integrated development all over the world. As a demonstration area for China's high-quality integrated development, the Yangtze River Delta Integrated Development Demonstration Zone should actively study the development experience of the Indonesia-Malaysia-Singapore Growth Triangle (IMS-GT), start from building an inter-regional cooperative innovation system and fostering a consensus culture, as well as activating effect of neighborhood. For the development model, it should be based on the coordination of inter-provincial system and mechanism, taking enterprises as the main body, innovation as the guide, and connecting international and domestic trades to achieve both virtual and real economy prosperity. With the implementation of reform measures, breakthroughs and system integration as the starting point, the government should deepen practical innovation, encourage multi-polar promotion and strengthen the integration of the same domain, through the improvement of top-level design. Thus, it will attract the best quality resources in the Yangtze River Delta and even the country, cultivate the global value chain, and strengthen the ability of companies and industrial clusters, to achieve its ultimate goal as a new benchmark, experimental field and new engine.